Page 21 - Hormel Report 2023

In eLife, we recently reported insights into the selection mechanism used by cPLA2α C2-domain to target phospha- tidyl-choline in membranes for arachidonic acid release. The findings could help develop new treatments for wound-heal- ing, sepsis, and other inflammation-associated pathologic conditions including cancer.
Research Support: Various NIH RO1 grants, The Hormel Foundation, and Southern Minnesota Paint the Town Pink.
ORCID iD: https://orcid.org/0000-0002-7337-3604
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Generation of small, homogeneour single-bilayer POPC vesicles by POPC/DHPC bicelle mix dilution
Recent Research Projects:
• Ceramide-1-Phosphate Transfer Protein (CPTP) Regulation: New Strategy for Enhancing Breast Cancer Therapeutics
• Development of a simplified approach for in vitro production of uniform-size, stable membrane vesicles used for measuring protein-membrane interaction by dilution of lipid bicelles as reported in Analytical Chemistry and Bio-protocol. The broad- reaching potential of this work led to patent filing by the UMN Technology Commercialization Office.
Ceramide-1-phosphate transfer protein (CPTP) with bound C1P interacting membrane containing PIP2
Congratulations to Dr. Brown on his retirement after 36 years at The Hormel Institute. Thank you, Dr. Brown, for your dedication, expertise, and significant contributions to science worldwide. Dr. Brown is now serving as Professor Emeritus, supporting The Hormel Institute’s current and incoming faculty with his great expertise and direction.