Page 10 - Annual Report 2020

Ilana Chefetz Menake
Cancer Stem Cells and Necroptosis
SECTION LEADER / ASSISTANT PROFESSOR
“We are trying
to identify and characterize
novel therapies that specifically target cancer stem cells taking into consideration that tumor cells are
heterogeneous.”
Ilana Chefetz Menaker
r, Ph.D.
Akimasa Takahashi Seda Vatansever Golla Naresh Imran Khan
Ester Molina Hoyo Tanner Conway Danielle Jamison Suad Mohamed
Our lab studies the molecular and metabol- or ischemia. However, recent studies now reveal
ic aspects of cell programmed necrosis
(necroptosis) in order to design targeted therapies and prevent recurrent disease. Cell programmed necrosis or necroptosis is a recently identified novel regulated cell death pathway. Cell death with necrotic morphology and features is thought to be a non-regulated and uncontrollable event associated with cell injury, inflammation
that necrosis can occur in regulated manner. Necroptosis participates in pathogenies of dis- eases including neurodegeneration, ischemia and heart disorders, and viral infections; thus target- ing necroptosis will prevent or mitigate undesir- able cell death. On the other hand, drugs, inducing necroptotic cell death in tumors, can potentially overcome drug resistance in cancer cells due to
SUMMARY
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