Page 14 - Annual Report 2020

Wioletta Czaja, Ph.D.
DNA Repair and Genome Stability
SECTION LEADER / ASSISTANT PROFESSOR
“The long-term objective of our research is to understand how stability of the human genome
is maintained and regu- lated in various cellular and tissue contexts to promote advances in novel anticancer therapy and personalized medi- cine. We employ modern approaches in biochem- istry, cell and molecular biology, genetics and genomics using fungal model organisms and human cell lines.”
Wioletta Czaja
Yong Li
Nearly all forms of cancer (~90%) contain lation of DNA damage and repair. The long-term
significant levels of genomic instability
(high frequency of mutations, chromosomal rearrangements), largely resulting from deficient or dysregulated DNA repair processes. The molecular events leading to genomic instability are not well understood. We investigate the fundamental mech- anisms protecting genomic integrity, with a special focus on the epigenetic and chromatin-based regu-
objective of our research is to understand how stability of the human genome is maintained and regulated in various cellular and tissue contexts
to promote advances in novel anticancer therapy and personalized medicine. We employ modern approaches in biochemistry, cell and molecular biology, genetics and genomics using fungal model organisms and human cell lines.
SUMMARY
^