Page 22 - Annual Report 2020
P. 22
Edward H. Hinchcliffe
Cellular Dynamics
SECTION LEADER / PROFESSOR
“We focus on the role of mitotic mechanisms in the generation of
human disease.”
Edward H. Hinchcliffe
, Ph.D.
Alyssa Langfald Charles Day
Our work seeks to understand the cellular into new methods of diagnosis, prevention and
basis for tumorigenesis. We study the
process where cells separate duplicated chromosomes into two daughter cells - called cell division or mitosis. Mistakes in mitosis lead to uneven chromosome segregations, which is a hallmark of cancer progression. Specifically, we study how changes to DNA (mutations) lead to chromosome missegregation during mitosis. By understanding the molecular mechanisms underly- ing these cellular defects, we will provide insight
treatment for cancer.
Chromosome missegregation:
Inadvertent chromosome missegregation in anaphase generates aneuploid cells, but the prolif- eration of these cells is normally blocked, because chromosome missegregation also triggers a p53- dependant failsafe that triggers cell cycle arrest in the ensuing G1. The molecular mechanisms under- lying this trigger are not known.
SUMMARY
^
