Page 28 - Annual Report 2020
P. 28

                                       Bin Liu, Ph.D.
Transcription and Gene Regulation
SECTION LEADER / ASSISTANT PROFESSOR
“Transcription is regulated by various transcription factors. Many human diseases and disorders are associated with misreg- ulation of transcription and mutations of transcription factors, including cancer, auto- immunity, neurological disorders, develop- mental disorders, diabetes, cardiovascular
disease, and obesity.”
Bin Liu
                                                                Wei Shi Yanan Jiang
                                  Our overall goal is to provide a structural basis the regulation of the RNAP by transcription factors
of the initiation, elongation and termination
of transcription and their regulations in bacteria. We shall study the formation of the tran- scription initiation complexes with various sigma factors, the transition from initiation to elongation and termination phases, the translocation of the RNA polymerase (RNAP) on template DNA, and
 at various stages of transcription. This objective will be achieved by determining the structures of the RNAP complexed with functionally associated proteins and appropriate DNA/RNA substrates captured at various steps in the processes, using cryo-electron microscopy and X-ray crystallography, as well as by appropriate biochemical experiments.
                   SUMMARY
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