Page 42 - Annual Report 2020

Chuanhe Yu, Ph.D.
Inheritance of Epigenetic Information
SECTION LEADER / ASSISTANT PROFESSOR
“Chromatin, which contains both genetic and epigenetic information, must be stably transmitted to daughter cells during mitotic cell divisions to maintain genome integrity and cell
identity.”
Chuanhe Yu
Yi Yang Jizhi Ge
Chromatin, which contains both genetic and replication. Mutations in chromatin regulators lead
epigenetic information, must be stably
transmitted to daughter cells during mitotic cell divisions to maintain genome integrity and cell identity. Nucleosomes, the basic repeating unit of chromatin, regulate access to the DNA for replica- tion, repair and transcription. Histone chaperones, histone modification enzymes and chromatin remodeling complexes are involved in chromatin
to genome instability and are frequently associated with human cancers. Furthermore, altered expres- sions of histone chaperones, which are involved
in DNA replication-coupled nucleosome assembly, have been linked to breast, gastrointestinal, laryn- geal, and prostate cancers. Thus, understanding how nucleosome assembly pathways are regulated will not only reveal how epigenetic information is
SUMMARY
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