Page 15 - Hormel Report 2021

Figure 1: Near atomic resolution structures of human plasma membrane transporters ABCA7 and ABCB1
Figure 2: Near atomic resolution structure of human peroxisomal membrane transporter ABCD1
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Current research projects:
1. Human ABCA family transporters and their
role in age in Alzheimer’s Disease Pathogene- sis (This project is currently funded by an NIH National Institute on Aging R21 grant (PI: Alam) and other age-related illnesses.
2. Mechanistic insight into P-glycoprotein/ABCB1/ MDR1 mediated drug-drug interactions, drug pharmacokinetics, and multidrug resistance.
3. Structural basis for ABCD1 mediated very long chain fatty acid (VLCFA) transport and its role in X-linked adrenoleukodystrophy.
4. Development of Nanobody binders against ABCB1 and ABCA7 (collaborative)
5. Understanding mechanisms of peroxisomal membrane protein insertion
6. Understanding mechanisms of peroxisomal matrix protein import
Publications:
• ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation.
• Aikawa T, Ren Y, Holm ML, Asmann YW, Alam A, Fitzgerald ML, Bu G, Kanekiyo T. Front Neurosci. 2021 Apr 7;15:647974. doi: 10.3389/fnins.2021. 647974. eCollection 2021.
• Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
• Nosol K, Romane K, Irobalieva RN, Alam A, Kowal J, Fujita N, Locher KP. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26245-26253. doi: 10.1073/ pnas.2010264117. Epub 2020 Oct 5.