Page 23 - Hormel Report 2021

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Current research projects:
1) Therapeutic potential of mesenchymal stem cell 2) Novel targeted therapies in ovarian cancer
3) AMPK-related proteins in ovarian cancer
4) Cell death and neurogenesis
Publications:
• Chesnokov MS, Khan I, Park Y, Ezell J, Mehta G, Yousif A, Hong LJ, Buckanovich RJ, Takahashi A, Chefetz I. The MEK1/2 Pathway as a Therapeutic Target in High-Grade Serous Ovarian Carcinoma. Cancers (Basel). 2021 Mar 18;13(6):1369. doi: 10.3390/cancers13061369. PMID: 33803586.
• Golla N., Hong L.J., Chefetz I. (2021) Visualization of Necroptotic Cell Death through Transmission Electron Microscopy. In: Alvero A.B., Mor G.G. (eds) Detection of Cell Death Mechanisms. Methods in Molecular Biology, vol 2255. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1162-3_12.
• Chesnokov M., Khan I., Chefetz I. (2021) Induction and Detection of Necroptotic Cell Death in Mammalian Cell Culture. In: Alvero A.B., Mor G.G. (eds) Detection of Cell Death Mechanisms. Methods in Molecular Biology, vol 2255. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1162-3_11.
• Takahashi A, Hong L, Chefetz I. How to win the ovarian cancer stem cell battle: destroying the roots. Cancer Drug Resist 2020;4:1021-1033. http://dx.doi. org/10.20517/cdr.2020.93.
• Imran Khan, Abdelrahman Yousif, Mikhail Chesnokov, Linda Hong, and Ilana Chefetz.
2020. A decade of cell death studies: breathing new life into necroptosis. Pharmacology and Therapeutics. 2020 Oct 24;107717. doi: 10.1016/j. pharmthera.2020.107717. PMID 33164841.
necroptosis is initiated by TNF-α while Caspases are inhibited using pan-Caspase inhibitor ZVAD-FMK, requires the kinase activity of Receptor-interacting proteins 1 and 3 (RIPK1 and RIPK3) followed by their downstream target MLKL. Necroptosis execution involves formation of micro-complex (20 MDa) necroptosome followed by disintegration of mitochondrial and plasma membranes. Despite necroptosis importance, many molecular downstream events are unknown or being disputed.