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We are also involved in a number of collaborative projects, including structural characterization of the HTLV-1 intasome (Fig. 2).
Figure 2. A hypothetical model of HTLV-1 intasome containing PP2A holoenzymes. Two copies of PP2A holoenzyme docked on the HTLV-1 intasome by superposition of the B56γ subunits, resulting in a snug fit between the catalytic C subunit of PP2A (red) and the catalytic domain of outer IN subunit (yellow and cyan) (Bhatt & Shi, et al, 2020).
Current research projects:
PROJECT 1: Endophilin B1-membrane remodeling and activation of Bax-dependent cell death
PROJECT 2: ABHD5-mediated membrane remodeling controls PNPLA2-controled lipolysis
PROJECT 3: Structural Basis for HTVL-1 hijacking of host factors
PROJECT 4: Structural basis for Huntingtin mis-folding
Publication:
• Bhatt, V., Shi, K., Salamango, D.J. et al. Structural basis of host protein hijacking in human T-cell leukemia virus integration. Nat Commun 11, 3121 (2020).
