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  Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppress- es EBV lytic reactivation and sensitizes tumors to radiation therapy. J. Hu, Y. Li, H. Li, F. Shi, L. Xie, L. Zhao, M.Tang, X. Luo, W.h. Jia, J. Fan,
J. Zhou, Q. Gao, S. Qiu, W.z. Wu, X. Zhang, W.h. Liao, A. M. Bode & Y. Cao. Theranostics. 10(26): 11921-11937. (2020).
COVID-19: The Impact in Oncology Care. U. Ray, F. Aziz, A. Shankar, A.S. Biswas, A. Chakraborty. SN Compr Clin Med. 1-10. (2020)
Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype- Universal Neutralizing Antibody Assay. K. Kro- tova, G. Aslanidi. Hum Gene Ther. 31(19-20): 1124–1131. (2020).
IntAPT: integrated assembly of phenotype-spe- cific transcripts from multiple RNA-seq profiles. X. Shi, A.F. Neuwald, X. Wang, T-L. Wang, L. Hilakivi-Clarke, R. Clarke, J. Xuan. Bioinformat- ics. 37(5): 650-658. (2020).
Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. K. Nosol, K. Romane, R. N. Irobalieva, A. Alam, J. Kowal, N. Fujita, & K.P. Locher. Proc Natl Acad Sci U S A. 117(42): 26245-26253. (2020).
SV-HotSpot: detection and visualization of hotspots targeted by structural variants associated with gene expression. A. M. Eteleeb, D.A. Quigley, S. G. Zhao, D. Pham, R. Yang, S.M. Dehm, J. Luo, F.Y. Feng, H.X. Dang & C.
A. Maher. Sci Rep. 10: 15890. (2020).
Biomarker function of HMGA2 in ultraviolet- induced skin cancer development. W. Ha, A. Hinde, L. Xie, M.H. Trager & L. Liu. Exp Dermatol. 29(10): 1021-1026. (2020)
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease. F. J. Caballero‐Camino, I. Rivilla, E. Herraez, O. Briz, A. Santos‐Laso,
L. Izquierdo‐Sanchez, Pui Y. Lee‐Law, P. M. Rodrigues, P. Munoz‐Garrido, S. Jin, E. Peixoto, S. Richard, S. A. Gradilone, et al. Hepatology. 73(1): 186-203. (2020)
ScanITD: Detecting internal tandem duplication with robust variant allele frequency estima- tion. T-Y. Wang & R. Yang. Gigascience. 9(8): giaa089. (2020).
A Systems Biology Approach to Discovering Pathway Signaling Dysregulation in Metastasis. Robert Clarke, Pavel Kraikivski, Brandon C. Jones, Catherine M. Sevigny, Surojeet Sengup- ta & Yue Wang Cancer Metastasis Rev. 39(3): 903-918. (2020).
UV biomarker genes for classification and risk stratification of cutaneous actinic keratoses and squamous cell carcinoma subtypes. D. Queen, Y. Shen, M. H. Trager, A.T. Lopez, F. H. Samie, J.M. Lewin, G.W. Niedt, L.J. Geskin & L. Liu. FASEB J. 34(9): 13022-13032. (2020).
IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells. A.L. Remoli, M. Sgarbanti, E, Perrotti, M. Acchioni, Roberto Orsatti, C. Acchioni, A. Battistini, R. Clarke & G. Marili. Neoplasia. 22(10): 459-469. (2020).
HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E. X. Chang, T. Zhang, Q.Wang, M. G. Rathore, K. Reddy,
H. Chen, S.H. Shin, W.-ya Ma & A.M. Bode. Theranostics. 10(21): 9721-9740. (2020).
Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration. Y. Colon-Cortes, M.A. Hasan & G. Aslanidi. Gene X. 2020 Dec; 5: 100037. (2020).
Synthetic lethality by targeting the RUVBL1/ 2-TTT complex in mTORC1-hyperactive cancer cells. S.H. Shin, Ji Su Lee, J-M. Zhang, S. Choi, Z.V. Boskovic, R. Zhao, M. Song, R. Wang, J. Tian, M-H. Lee, J. H. Kim, M. Jeong, J.H. Lee, M. Petukhov, S.W. Lee, S.G. Kim, L. Zou & S. Byun. Sci Adv. 6(31): eaay9131. (2020).
Identifying and treating ROBO1−ve/DOCK1+ve prostate cancer: An aggressive cancer sub-type prevalent in African-American patients. M. G. Ferrari, A. A. Ganaie, A. Shabenah, A. P. Mansini, L. Wang, P. Murugan, E. Davicioni, J. Wang, Y. Deng, L. H. Hoeppner, C. A. Warlick, B. R. Kone- ty & M. Saleem. Prostate. 80(13): 1045-1057. (2020).
DNA methylation landscapes in advanced prostate cancer. S.G. Zhao, W.S. Chen, H. Li,
A. Foye, M. Zhang, M. Sjöström, R. Aggarwal,
D. Playdle, A. Liao, J.J. Alumkal, R. Das, J. Chou, J.T. Hua, T.J. Barnard, A.M. Bailey, E. Chow, M. Perry, H.X. Dang, R. Yang, et al. Nat Gene. 52(8): 778–789. (2020).
Are FDA-Approved Sunscreen Components Effective in Preventing Solar UV-Induced Skin Cancer? A.M. Bode & E. Roh. Cells. 9(7):1674. (2020).
BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases. F. Grigore, H. Yang, N.D. Hanson, M.W. VanBrocklin, A.L. Sarver
& J.P. Robinson. Neoplasia. 22(9): 376-389. (2020).
Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer. M. Fan, P. Xia, R. Clarke, Y. Wang & L. Li. Nat Commun. 11(1):486. (2020).
ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumor cell proliferation. S.K. Alam, L. Wang, Y. Ren, C.E. Hernandez, F. Kosari, A.C. Roden, R. Yang & L.H. Hoeppner. Br J Cancer. 123(5):819-832. (2020).
RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor. A. Calderon-Aparicio,
H. Yamamoto, H. De Vitto, T. Zhang, Q. Wang, A.M. Bode, et al. Mol Cancer Res. 18(11):1660- 1674. (2020).
ARC Is a Critical Protector against Inflammatory Bowel Disease (IBD) and IBD-Associated Col- orectal Tumorigenesis.Q. Wang, T. Zhang,
X Chang, D.Y. Lim, K. Wang, R. Bai, T. Wang,
J. Ryu, H. Chen, K. Yao, WY Ma, LA Boardman, A.M. Bode, et al. Cancer Res. 1;80(19):4158- 4171. (2020).
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway. K. Krotova, N. Khodayar, R. Oshins G. Aslanidi. & M.L. Brantly. Sci Rep.10(1):15874. (2020).
Structural Basis for the Regulation of Biofilm Formation and Iron Uptake in A. baumannii by the Blue-Light-Using Photoreceptor, BlsA. I. Chitrakar, J.N. Iuliano, Y. He, H.A. Woroniecka, J Collado Tolentino, J.M.
Wint, S.G. Walker, P.J. Tonge & J.B. French. ACS Infect Dis 9;6(10):2592-2603. (2020).
| 65 Unraveling the Mechanism of a LOV Domain
Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix. J.N. Iuliano, J.T. Col- lado, A.A. Gil, P.T. Ravindran, A. Lukacs, S. Shin, H.A. Woroniecka, K. Adamczyk, J.M. Aramini, U.R. Edupuganti, C.R. Hall, G.M. Greetham, I.V. Sazanovich, I.P. Clark, T. Daryaee, J.E. Toettch- er, J.B. French, K.H. Gardner, C.L. Simmerling, S.R. Meech & P.J. Tonge. ACS Chem Biol. 15(10):2752-2765. (2020).
Cholangiocarcinoma 2020: the next horizon in mechanisms and management. J.M. Banales , J.J.G. Marin, A. Lamarca, P.M. Rodrigues,
S.A. Khan, L.R. Roberts, V. Cardinale, G. Carpi- no, J.B. Andersen, C. Braconi, D.F. Calvisi, M.J. Perugorria, L. Fabris, L. Boulter, R.I.R. Macias, E. Gaudio D. Alvaro, S.A. Gradilone, et al. Nat Rev Gastroenterol Hepatol. 17(9):557-588. (2020).
ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation. S.K. Alam, L. Wang, Y. Ren, C.E. Hernandez, F. Kosari, A.C. Roden & R. Yang & L.H. Hoeppner. Br J Cancer. 123(5):819-832. (2020).
Structural basis of bacterial σ28 -mediated transcription reveals roles of the RNA poly- merase zinc-binding domain. W. Shi, W. Zhou, B. Zhang, S. Huang, Y. Jiang, A. Schammel, Y. Hu & B. Liu. EMBO J. 15;39(14):e104389. (2020).
Targeting RET Kinase in Neuroendocrine Pros- tate Cancer. H.R. VanDeusen, J.R. Ramroop , K.L. Morel, S.Y. Bae , A.V. Sheahan, Z. Sychev, N.A. Lau, L.C. Cheng, VM Tan, Z. Li, A. Petersen, J.K. Lee, J.W. Park , R. Yang, et al. JM. Mol Cancer Res. 18(8):1176-1188. (2020)
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. A.C. Nelson, TJ Turbyville, S. Dharmaiah, M. Rigby, R. Yang, TY Wang, J. Columbus, R. Stephens, T. Taylor, D. Sciacca, G. Onsongo, A. Sarver, S. Subramanian S, D.V. Nissley, D.K. Simanshu & E. Lou.J Biol Chem. 10;295(28):9335-9348. (2020)























































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