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INTEGRATIVE BIOLOGY & PHYSIOLOGY t 13 tIBP AT A GLANCE Core Contact:Pilar Ariza Guzman, DVM, MSariza001@umn.edu / 612-624-0974The Physiology Core is an Internal Service Organization (ISO) created by the Integrative Biology and Physiology Department to offer University of Minnesota faculty highly specialized equipment, surgical and technical expertise and data analysis capability in the area of metabolic and cardiovascular phenotyping and stress physiology. Alessandro Bartolomucci, PhD, is the Core Director, Pilar Ariza-Guzman, DVM, MS, is Core Manager, and Maria Razzoli, PhD, is the Metabolism and Behavior Specialist.The Physiology Core, is located in the Cardio-Cancer Research Building (CCRB) and is also a core facility of the Masonic Institute for the Biology of Aging and Metabolism (med.umn.edu/aging) and the Institute for Diabetes, Obesity and Metabolism.Major services include: %u2022 Whole animal energy expenditure: Oxymax/CLAMS-HC Lab Animal Monitoring System (Columbus Instruments, Columbus, OH).%u2022 Body composition and organ fat and fat-free composition (Echo-MRI 3-in-1, Echo Medical Systems LLC, Houston, TX).%u2022 Automated Food Consumption and meal pattern analysis (BioDaq, Reseach Diets, Inc.).%u2022 Cardiovascular functions in freely moving rodents using Data Science%u2019s radiotelemetry system (Data Science International, St. Paul, MN).%u2022 Non-Invasive Blood Pressure Measurement (CODA, Kent Scientific).%u2022 Running wheels and other exercise physiology tests.%u2022 Non-invasive measure of body temperature (Anipill, Animal Monitoring).%u2022 Specialized surgery and echocardiography analysis in mice and rats.News for 2024-2025The Core is now supported by the Masonic Institute for the Biology of Aging and Metabolism. This recognizes a strategic partnership to advance the physiological phenotyping of mouse models of aging-related diseases and to illuminate the physiological significance of basic mechanisms of aging. The Physiology Core acquired the newest Oxymax/CLAMS-HC: Metabolic Monitor for Home Cages, manufactured by Columbus Instruments International Corporation. The CLAMS-HC functionalities include high sensitivity respirometry to estimate energy expenditure and respiratory exchange ratio, combined with automated and integrated measure of food intake, body weight and locomotor activity, all within a home cage-like environment. The system available at the Physiology Core also includes environmental enclosures allowing full control of light cycle and temperature. The purchase of the CLAMS-HC was made possible thanks to a 2024 Research Infrastructure Investment Program award from the UMN Medical School, with financial support by the Department of Integrative Biology and Physiology, the Institute for Diabetes, Obesity and Metabolism, the Department of Surgery, the Department of Neuroscience, the Muscular Dystrophy Center, and Dr. David Bernlohr.Economic and scientific impact of the core:Approximately 70% of the billings were from sponsored accounts. For all those grants (intramural and extramural), independently from the $ spent in the core, there is no alternative to the service offered by the Physiology Core for performing the proposed experiments. The vast majority of these grants were from NIH, others included: DOD, ADA, AHA, etc.Since its inception in 2015, the Core has served over 75 (17 in FY25) PIs affiliated with more than 15 different departments, spanning four different schools at the University of Minnesota. The Core is also central to several P-type and U-type NIH grants and supports the research of several T32 training grants.Physiology CoreDr. Lisa Carney Andersonhas been inducted into the Academy for Excellence in the Scholarship of Teaching and Learning at the University of Minnesota.Dr. Emilyn Alejandrowas chosen as a Fellow in the 2025-2026 Hedwig van Ameringen Executive Leadership in Academic Medicine%u00ae (ELAM) Program.Congratulations Lisa! Congratulations Emilyn!