Page 11 - IBP In Focus Newsletter

t IBP AT A GLANCE
Core Contact:
Pilar Ariza Guzman, DVM, MS ariza001@umn.edu / 612-624-0974
INTEGRATIVE BIOLOGY & PHYSIOLOGY t 11
Physiology Core
The Physiology Core is an Internal Service Organization (ISO) created by the Integrative Biology and Physiology Depart- ment to offer University of Minnesota faculty highly specialized equipment, surgical and technical expertise and data anal- ysis capability in the area of metabolic and cardiovascular phenotyping and stress physiology. Alessandro Bartolomucci, Ph.D., is the Core Director, Pilar Ariza-Guzman, D.V.M., M.S., is Core Manager, and Maria Razzoli, Ph.D., is the Metabolism and Behavior Specialist.
The Physiology Core, is also a core facility of the Institute for Diabetes, Obesity and Metabolism (IDOM. Elizabeth Seaquist, David Bernlohr, Co-Directors) and is partially funded by the Academic Investment Research Program (“AIRP”) of the University of Minnesota.
Major services include:
• Whole animal energy expenditure: Oxymax/CLAMS Lab Animal Monitoring System (Columbus Instruments,
Columbus, OH).
• Body composition and organ fat and fat-free composition (Echo-MRI 3-in-1, Echo Medical Systems LLC,
Houston, TX).
• Automated Food Consumption and meal pattern analysis (BioDaq, Research Diets, Inc.).
• Cardiovascular functions in freely moving rodents using Data Science’s radiotelemetry system (Data Science
International, St. Paul, MN). New to the Core is the acquisition in collaboration with the Lillehei Heart Institute of
a 16 channels Ponemah system to allows automated ECG analysis.
• Non-Invasive Blood Pressure Measurement.
• Specialized surgery and echocardiography analysis in mice and rats.
Economic impact of the core:
Approximately 70% of the billings were from sponsored accounts. For all those grants (intramural and extramural), independently from the money spent in the core, there is no alternative to the service offered by the Physiology Core for performing the proposed experiments. The vast majority of these grants were from NIH, others included: ADA, AHA, etc. The total annual direct cost awarded to the grants used to pay Core service in fiscal year 2021 is over $3.7M, and the total indirect costs is over $1.5M. This is an underestimation of the economic impact of the core because it is difficult to provide similar figures for intramural grants (some of which are competitive grants such as the MN Partnership, Wallin Neuroscience Discovery Fund, etc.).
Scientific impact of the core:
Since its inception in 2015, the Core has served over 75 PIs affiliated with more than 15 different departments, spanning four different schools at the University of Minnesota. In FY21 the Core supported 30 grant proposal (NIH, ADA, Foundations, etc.) that included one or more Physiology Core service.
A few examples of papers published in 2020-2021 which were supported by the Core is listed below:
Asirvatham-Jeyaraj N, Gauthier MM, Banek CT, Ramesh A, Garver H, Fink GD, Osborn JW. Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive Schlager (BPH/2J) Mice. Hypertension. 2021 Feb;77(2):519-528. doi: 10.1161/HYPERTENSIONAHA.119.14069.
Kulhanek D, Weigel R, Paulsen ME. Maternal High-Fat-High-Carbohydrate Diet-Induced Obesity Is Associated with Increased Appetite in Peripubertal Male but Not Female C57Bl/6J Mice. Nutrients. 2020 Sep 24;12(10):2919. doi: 10.3390/nu12102919.
Zhao M, Ren K, Xiong X, Cheng M, Zhang Z, Huang Z, Han X, Yang X, Alejandro EU, Ruan HB. Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells. Cell Rep. 2020 Aug 11;32(6):108013. doi: 10.1016/j.celrep.2020.108013.
The main Core facility is located in the Cardio-Cancer Research Building (CCRB), while select services are also available on the 1st floor of Jackson Hall.